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SRX587766: GSM1409240: RD3; Homo sapiens; RNA-Seq
1 ILLUMINA (Illumina HiSeq 2000) run: 50.3M spots, 2.6G bases, 1.7Gb downloads

Submitted by: Gene Expression Omnibus (GEO)
Study: The BCL6 RD2 domain governs commitment of activated B-cells to form germinal centers
PRJNA252112 • SRP043078 • All experiments • All runs
show Abstracthide Abstract
Our data demonstrated that Bcl6 directly binds and represses trafficking receptors S1pr1 and Grp183 by recruiting Hdac2 through the RD2 domain. Deregulation of these genes impairs B-cell migration and may contribute to the Germinal Center failure in Bcl6RD2MUT mice. Overall design: RNAseq was performed in endogenous BCL6-depleted OCI-LY1 cells rescued with either WT or RD mutant BCL6 (N=3 for each group).
Sample: RD3
SAMN02849462 • SRS633559 • All experiments • All runs
Organism: Homo sapiens
Library:
Instrument: Illumina HiSeq 2000
Strategy: RNA-Seq
Source: TRANSCRIPTOMIC
Selection: cDNA
Layout: SINGLE
Construction protocol: Cells were dissolved in Trizol and total RNA was extracted according to the Trizol protocol (Life Technologies, Cat. No. 15596-018). Libraries were constructed according to the Illumina Truseq RNA sample preparation guide.
Experiment attributes:
GEO Accession: GSM1409240
Links:
External link:
Runs: 1 run, 50.3M spots, 2.6G bases, 1.7Gb
Run# of Spots# of BasesSizePublished
SRR137343450,328,3472.6G1.7Gb2014-09-17

ID:
833521

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